Figure 3

Neuropathology in HD monkey frontal cortex. A-F) An increased number of caspase-3 positive cells in frontal cortex of HD monkeys (D-E) was observed when compared with control monkeys (A-B). C) Quantification of caspase-3 positive cells in HD and control monkey frontal cortex showed significant difference between HD monkeys (HD7 and HD8) and control monkey (C1 or C3). However, no difference was observed between HD4 and the controls. The data are presented as mean ± SE. *P < 0.05 compared with C1, and ^#P < 0.05 compared with C3. G-L) An increased number and intensity of GFAP positive cells was observed in HD monkeys (HD7 and HD8) but not in HD4 (J-L). High magnification (inserts) showed reactive astrocytes in HD7 and HD8 with strong GFAP staining. Quantification of GFAP expression in the HD monkey frontal cortex showed significant increase expression of GFAP in HD7 and HD8 but not in HD4. The data were presented as mean ± SE. *P < 0.05