Figure 7
From: Rapid and Direct Transport of Cell Surface APP to the Lysosome defines a novel selective pathway
APP is rapidly internalized to the lysosome in live Cos7 cells. Cos7 cells were transiently co-transfected with wild type full length FL-APP-CFP (A) or βAPP-CFP (B) constructs along with the LAMP1-mRFP compartment marker construct. Individual cells were selected and fluorescently-labeled anti-HA antibody was added to the media. Laser confocal images were then acquired at approximately 2 frames/min.