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Figure 4 | Molecular Brain

Figure 4

From: Schizophrenia, amphetamine-induced sensitized state and acute amphetamine exposure all show a common alteration: increased dopamine D2 receptor dimerization

Figure 4

Amphetamine facilitates D2R dimerization in rat striatal neurons. A-B, Western blot analysis of the expression levels of D2R dimers (A) and monomers (B) in primary cultures of rat striatal neurons treated with or without AMPH (30 min, 10 μM). ***Significantly different from control group (p < 0.001; n = 5). Data were analyzed by t-test. C-D, Western blot analysis of the expression levels of D2R dimers (C) and monomers (D) in primary cultures of rat striatal neurons treated with quinpirole (10 μM), dopamine (10 μM) or AMPH (10 μM). *, **Significantly different from control group (p < 0.05, p < 0.01; n = 5). Data were analyzed by One-way ANOVA, followed by SNK post-hoc test. E-F, Western blot analysis of the expression levels of D2R dimers (E) and monomers (F) in HEK-293T cells transfected with D2R in the presence or absence of AMPH (30 min, 10 μM; n = 3).

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Molecular Brain

ISSN: 1756-6606