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Figure 4 | Molecular Brain

Figure 4

From: Calcium/calmodulin-dependent kinase IV contributes to translation-dependent early synaptic potentiation in the anterior cingulate cortex of adult mice

Figure 4

A translation inhibitor has no effect on basal synaptic transmission. A: No effect of anisomycin (20 μM) on AMPA receptor-mediated EPSCs in ACC neurons of wild-type mice (n = 8/5 mice). B: No effect of anisomycin on NMDA receptor-mediated EPSCs in ACC neurons of wild-type mice (n = 8/5 mice). C: No effect of anisomycin on AMPA receptor-mediated EPSCs in ACC neurons of CaMKIV transgenic (TG) mice (n = 8/5 mice). D: No effect of anisomycin on NMDA receptor-mediated EPSCs in ACC neurons of CaMKIV TG mice (n = 9/5 mice). A-D: The dashed line indicating the mean basal synaptic responses. The insets showing verages of five EPSCs at baseline responses (a) and 25-30 min (b) after application of anisomycin (black bar).

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Molecular Brain

ISSN: 1756-6606