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Figure 5 | Molecular Brain

Figure 5

From: Impairment of adult hippocampal neural progenitor proliferation by methamphetamine: role for nitrotyrosination

Figure 5

Effects of antioxidants on METH-induced cell death of NPCs. NPCs were preincubated for 2 hrs with either Trolox (10 uM) or uric acid (UA, 25 or 250 uM), followed by addition of METH (250 uM). Cells were analyzed at 48 hours. (A) Protein lysates were subjected to Western blotting with antibody against 3-nitrotyrosine. Both Trolox and Uric acid markedly decrease nitrotyrosination of a number of NPC proteins. (B). Both Trolox and Uric acid protect against METH-induced NPC death and decrease reactive oxygen species-induced nitrotyrosination (** p <0.01, ANOVA).

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Molecular Brain

ISSN: 1756-6606