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Figure 6 | Molecular Brain

Figure 6

From: Impairment of adult hippocampal neural progenitor proliferation by methamphetamine: role for nitrotyrosination

Figure 6

METH induces nitrotyrosination of PKM2 and inhibits its activity. A. NPC lysates were immunoprecipitated with antibody to 3-nitrotyrosine, and ratio of nitrotyrosinated to total PKM2 is quantified. B. Assessment of pyruvate kinase activity in NPC lysates. C. 3-nitrotyrosine Western blotting (above) and pyruvate kinase activity (below) of recombinant PKM2 (control or peroxynitrite treated). *p <0.05, ***p <0.001 ANOVA.

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Molecular Brain

ISSN: 1756-6606