Figure 3From: Loss of glutathione homeostasis associated with neuronal senescence facilitates TRPM2 channel activation in cultured hippocampal pyramidal neuronsGlutathione inhibits TRPM2 currents in hippocampal pyramidal neurons. (A) 10 mM GSH in the patch pipette significantly inhibits TRPM2 currents generated by 1 mM ADPR with an NMDAR stimulation protocol (p = 0.04). (B, C) Representative traces of control and GSH inhibition with the NMDAR stimulation protocol. (D)10 mM GSH in the patch pipette significantly inhibits TRPM2 currents generated by 1 mM ADPR with a voltage ramp protocol (p = 0.01). (E,F) Representative traces of control and GSH inhibition with the voltage ramp protocol.Back to article page