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Figure 2 | Molecular Brain

Figure 2

From: Activation of c-jun N-terminal kinase in spinal cord contributes to breast cancer induced bone pain in rats

Figure 2

Intra-tibial inoculation of carcinoma cells induced persistent JNK activation on the ipsilateral side of L4-L5 spinal cord. (A-C) Time course of pJNK activation in ipsilateral side of L4-L5 spinal cord. (D) Quantitative measurement of pJNK-IR cells in the superficial dorsal horn (laminas I- III). (E-M) Double immunofluorescence of pJNK (green) with NeuN (red, E-G), CD11b (H-J) and GFAP (red, K-M) respectively. (N) Statistic analysis of pJNK1/2-IR cells co-expressed with NeuN, CD11b and GFAP. Scale bars: 50 μm. (G’, J’, M’) High magnification image of G, J and M. Scale bars: 50 μm. (** p < 0.01 vs Naive, one-way ANOVA, mean ± SEM, n = 4)

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Molecular Brain

ISSN: 1756-6606