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Figure 2 | Molecular Brain

Figure 2

From: Fragile X mental retardation protein and synaptic plasticity

Figure 2

FMRP and Kv4.2 regulate the threshold for inducing synaptic potentiation. (A) FMRP sets the threshold for LTP and STD-LTP. Fmr1 KO mice have deficient hippocampal LTP and cortical STD-LTP only with a “weak” induction protocol. (B) Kv4.2 is a dendritic A-type K+ channel that attenuates action potential backpropagation (bAP) and dendritic excitability. (C) Inhibition of Kv4.2 restores LTP following a weak induction protocol in Fmr1 KO mice.

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Molecular Brain

ISSN: 1756-6606