Figure 2

Recovery of impaired oligodendrocytes, myelin, and endothelial cells in LPS-injected SNpc. (A, C) At the indicated times after LPS injection, sections were labeled with antibodies specific for markers of oligodendrocytes (CC1) and endothelial cells (SMI 71). (B) For myelin staining, sections were stained with ECRC. (A-C) Lower panels are higher magnification images of boxed areas in upper panels. Contralateral (Contra) sides of LPS-injected animals and PBS-injected animals were used as controls. (D) ECRC- and SMI 71-negative areas were quantified at the indicated times. Values are means ± SEMs of more than three samples (*p < 0.01; **p < 0.001; Student’s t-test). Asterisks (*) indicate drug injection sites. Scale bars, 1 mm (upper panels in A, B), 200 μm (upper panels in C), 100 μm (lower panels in B, C), and 50 μm (lower panels in A).