Figure 4
From: Post-transcriptional regulation of GABAB receptor and GIRK1 channels by Nogo receptor 1
Changes in GABAB and GIRK by down-regulation of NgR1 in plasma membrane and synaptosomes. A. In vitro biotinylation of hippocampal neurons in culture shows increased GABAB R1, GABAB R2 and GIRK1 in the membrane fraction in cells treated with NgR1 siRNA. B. Increased GABAB R2, GIRK1 and to a lesser extent GABAB R1 were found in a synaptosomal preparation from hippocampal region from NgR1 knockout mice. C. Quantitative analysis of results presented in B. Each sample was calculated as a ratio to β-actin and is presented as percentage of control. * P < 0.05.