Figure 1From: Chronic brain inflammation causes a reduction in GluN2A and GluN2B subunits of NMDA receptors and an increase in the phosphorylation of mitogen-activated protein kinases in the hippocampusPerformance of aCSF- and LPS-infused rats in the spatial version of a Morris water maze. (A) Search error in finding a hidden platform in a spatial learning task during 5 training trial blocks. The artificial cerebrospinal fluid (aCSF)-infused rats (labeled as aCSF) became proficient at locating the submerged platform during training. The lipopolysaccharide (LPS)-infused rats (labeled as LPS) showed less improvement over the course of training when compared with the aCSF-infused rats (*, p < 0.05). (B) The percentage of time spent in the target annulus which was 5 times of the platform size, during the 30Â s probe trial. The aCSF-infused rats spent more time in the target area than the LPS-infused rats, and this was statistically significant at the third probe trial (*, p < 0.05).Back to article page