From: Genes and signaling pathways involved in memory enhancement in mutant mice
Mutant | LTP phenotypes | Memory phenotypes | Reference |
---|---|---|---|
Psd-95 KO | Enhanced CA1 LTP | Impaired in MWM | [129] |
Limk-1 KO | Enhanced CA1 LTP | Normal initial learning, impaired reversal learning in MWM | [134] |
Syndecan-3 KO | Enhanced CA1 LTP | Impaired in MWM | [135] |
PTPδ KO | Enhanced CA1 and CA3 LTP | Impaired in MWM, RAM | [136] |
IRSp53 KO | Enhanced CA1 LTP | Impaired in MWM, ORT | [137] |
G iα1 KO | Enhanced CA1 LTP | Impaired in CFC, PA, ORT; but normal in MWM | [138] |
Tropomodulin-2 KO | Enhanced CA1 LTP | Impaired in CFC, MWM | [139] |
Dystrophin KO | Enhanced CA1 LTP | Impaired in MWM, ORT | [140] |
Tsc2 KO | Enhanced CA1 LTP | Impaired in MWM, CFC* | [114] |
GluR2 (GluA2) KO | Enhanced CA1 LTP | Impaired in MWM | |
Fmr2 KO | Enhanced CA1 LTP | Impaired in CFC, but normal in MWM | [133] |
dnPAK Tg | Enhanced cortical LTP | Impaired in MWM (21Â days), CFC (1Â day) | [143] |
Inositol 1,4,5-triphosphate 3-kinase KI | Enhanced CA1 LTP | No change in MWM | [144] |