Figure 5
From: Genome-wide screen for modifiers of Na+/K+ATPase alleles identifies critical genetic loci
Genetic interaction between Spz5 and ATPalpha . ATPalpha/Spz5 double mutants and ATPalpha*, Spz5 RNAi flies for each ATPalpha mutant were assayed and compared to ATPalpha* heterozygous controls. The RNAi knockdown was driven with da-Gal4. The genotypes in each graph are: ATPalpha*/+ (green), Spz5E03444/ATPalpha* (red), daGal4,ATPalpha*/+ (blue), and Spz5-RNAi/daGal4,ATPalpha* (orange). Spz5 mutants significantly enhanced the ATPalphaDTS1 phenotype but Spz5 RNAI significantly suppresses the ATPalphaDTS1 phenotype. The ATPalphaCJ10 phenotype is suppressed in both the Spz5 mutant and RNAi. The ATPalphaCJ5 phenotype was not significantly affected by loss of Spz5. *p < 0.05, **p < 0.01, ***p < 0.001.