Fig. 3
From: Understanding the molecular basis of autism in a dish using hiPSCs-derived neurons from ASD patients
Phenotypic analyses of iPSC-derived neurons. Patient-specific iPSCs are generated from human somatic cells. After characterization, expansion, and stabilization of iPSCs, ASD patient-derived human neurons are induced. These differentiated neurons can be characterized by changes in neuronal differentiation, morphological properties, electrophysiological properties, or gene expression network to elucidate molecular pathogenic mechanisms associated with ASD such as synaptopathy