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Fig. 6 | Molecular Brain

Fig. 6

From: The novel protein kinase C epsilon isoform modulates acetylcholine release in the rat neuromuscular junction

Fig. 6

Graphic representation of the central role of nPKCε activity in the regulated coupling of PKC to ACh release potentiation. The diagram illustrates several conditions that are known to couple PKC to enhance ACh release in the NMJ: electrical stimulation (1 Hz), high Ca2+ inflow, stimulation with phorbol ester (PMA), PKA stimulation with Sp-8-BrcAMP, and the interference with presynaptic mAChR (with atropine –AT–) and AR (with adenosine –ADO–). In all these conditions, preincubation with the specific nPKCε translocation inhibitor peptide εV1-2 impairs the PKC coupling and highlights the nPKCε isoform role in the modulation of ACh release in this synapse

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Molecular Brain

ISSN: 1756-6606