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Fig. 1 | Molecular Brain

Fig. 1

From: NMDA receptor agonists reverse impaired psychomotor and cognitive functions associated with hippocampal Hbegf-deficiency in mice

Fig. 1

Generation and determination of restricted HB-EGF deletion in Hbegf cKO mice. a Genomic structure and the design of the Hbegf cKO mice. b Genotyping of Hbegf cKO mice by PCR. c Regional specificity of Hbegf deletion. LacZ staining of Hbegf cKO mice brain section shows specific expression of lacZ in parts of the brain including the hippocampal CA1, CA3 and dentate gyrus (DG) regions, and the cerebellar granule cell layer. d Brain coronal sections with LacZ staining in Hbegf cKO mice. LacZ positive cells are indicated by arrow heads. e Quantitative analysis of Hbegf mRNA expression in brain regions. n = 4 (Control), n = 4 (cKO). Values are the means ± s.e.m. Olf, olfactory bulb; Str, striatum; Cor, cortex; Hip, hippocampus; Cere, cerebellum

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Molecular Brain

ISSN: 1756-6606