Fig. 2

Decreased locomotor activity and altered anxiety-like behavior in older C57BL/6J mice. a-h Open field test: a, e distance traveled (cm), b, f vertical activity, c, g center time (s), and d, h stereotypic counts during the first 5-min and the entire 120-min period of the test. i-l Light/dark transition test: i distance traveled (cm) in the light and dark chambers, j number of transitions, k latency to enter the light chamber (s), and l time spent in the light chamber (s). m-p Elevated plus maze test: m Distance traveled (cm), n number of arm entries, o entries into open arms (%), and p time spent in open arms (%). Values are means ± SEM. *p < 0.05, **p < 0.01, and ***p < 0.001 after Bonferroni correction performed when ANOVAs reached nominal significance. †p < 0.05 after Bonferroni correction performed when ANOVAs reached study-wide significance