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Table 4 Mean total number of PV+ and VVA+ cells in the SSC of Shank1-/- and in the striatum of Shank3B-/- mice in comparison to WT (PV+/+) mice in the two ROIs

From: Reduction in parvalbumin expression not loss of the parvalbumin-expressing GABA interneuron subpopulation in genetic parvalbumin and shank mouse models of autism

 

SSC PV+

SSC VVA+

 

Mean

Range

p-value

Mean

Range

p-value

PV+/+

153729

144,549–166,441

 

149709

129,498–169,086

 

Shank1-/-

96000

85,803–114,459

<0.0001

143392

128,601–166,705

0.6250

 

striatum PV+

Striatum VVA+

 

Mean

Range

p-value

Mean

Range

p-value

PV+/+

23332

22,384–25,012

 

21724

20,003–24,431

 

Shank3B-/-

12881

10,132–14,808

<0.0001

19951

16,887–22,811

0.1910