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Fig. 8 | Molecular Brain

Fig. 8

From: Amyloid Precursor-Like Protein 2 deletion-induced retinal synaptopathy related to congenital stationary night blindness: structural, functional and molecular characteristics

Fig. 8

APLP2 is required for the differentiation of bipolar cells and synaptogenesis of cone and rod terminals during postnatal development. Longitudinal cryostat sections of retinas from the indicated stages of postnatal development were immunostained for (a and b) PKCα, (c, C1 and e) VGLUT1 and (d) PSD95. C1 shows magnified IPL from PN10 and PN30 retinas. Retina sections were double immunostained for APLP2 (green) and VGLUT1 (red) (c and C1), and for APLP2 (green) and PSD95 (red) (d). Expression of VGLUT1 was analyzed to investigate temporal ordering in development of rod versus cone terminals in the OPL. 50 μm (a, c and e) and 20 μm (b)

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Molecular Brain

ISSN: 1756-6606