Fig. 8
From: Orchestrated activation of mGluR5 and CB1 promotes neuroprotection
Neuroprotection induced by CDPPB, URB597 and JZL184 is dependent on both ERK1/2 and AKT. a Graph shows cell death levels of corticostriatal neurons from either PI3Kγ+/+ or PI3Kγ−/− embryos that were either untreated (−) or treated (+) with 50 μM glutamate, 100 nM CDPPB, 1 nM URB597 and 10 nM JZL184 for 4 h. Data represent the means ± SEM of four independent experiments. * indicates significant difference as compared to matched treated PI3Kγ+/+ neurons and # indicates significant difference as compared to glutamate-treated PI3Kγ−/− neurons (p <0.05). Graphs show cell death levels of primary cultured corticostriatal neurons that were either untreated (−) or treated (+) with 50 μM glutamate, 100 nM CDPPB, 1 nM URB597, 10 nM JZL184, 1 μM LY294002 (b) and 10 μM PD98059 (c) for 4 h. Data represent the means ± SEM of four independent experiments. n.s. indicates not significant and * indicates significant difference as compared to glutamate treated neurons (p <0.05)