Fig. 4
Intra-ACC injection of GABAAR agonist induced anxiety-like behavior. A A schematic of the experimental design. B Representative figures show the anatomical localization of the rACC. C PWTs of model rats that received muscimol (GABAAR agonist) injections. D Quantification of behavioral parameters in the OF. (a) the percentage of distance in the central zone, (b) time in the central zone, (c) the number of entries into the central zone, (d) and the total distance traveled throughout the arena of the Model + ACSF group and Model + picrotoxin group. E Quantification of behavioral parameters in the in EZM. (a) the percentage of distance in the open arm, (b) time in the open arm, (c) the number of entries into the open arm of the Model + ACSF group and Model + picrotoxin group. F Quantification of behavioral parameters in the MBT. G Quantification of behavioral parameters in the NSF. (a) The time of latency to feed, (b) and the food consumption. The trajectories of rats in the Model + ACSF group and Model + picrotoxin group in the OF (I) and EZM (J). All data represent the mean ± SEM, n = 8. *P < 0.05, **P < 0.01, compared to the Model + ACSF group