Fig. 3

Altered synaptic plasticity in hippocampal CA1 in CA1-p35 cKO mice. A I–O curve of the Shaffer collateral-CA1synapse in CA1-p35 cKO and WT mice. There was no clear difference in synaptic strength between the two genotypes (n = 5). B Paired-pulse facilitation (PPF) ratio was not altered in CreER-p35 cKO mice compared with that in p35-flox mice (n = 5). C LTP-induction by TBS in hippocampal CA1 in CA1-p35 cKO was similar to that in WT mice (n = 5). D LTP-induction by tetanus stimuli in hippocampal CA1 in CA1-p35 cKO mice were not distinguishable from that in WT mice (n = 6). E NMDAR-dependent LTD with glutamate transporter inhibition in hippocampal CA1 in CA1-p35 cKO and WT mice. NMDAR-dependent LTD was significantly impaired in CA1-p35 cKO mice (n = 5). Error bars represent SEM. ***, p < 0.001, two-way repeated-measures ANOVA