Fig. 3

Post-SE mPGES-1 inhibition is neuroprotective. Neuronal injuries in the hippocampus (A), cortex (B), and amygdala (C) were visualized by Fluoro-Jade B (FJB) staining 4 d after pilocarpine-induced SE in mice that were treated by vehicle or compound PBCH. Scale bar = 100 μm. FJB-positive cells per section were counted in these brain areas and used for quantification of neurodegenerating neurons in each mouse brain for comparisons (N = 8, *P = 0.0275 for hippocampal CA1; **P = 0.0027 for CA3; *P = 0.0399 for dentate hilus; *P = 0.0367 for temporal cortex; P = 0.1314 for ectorhinal and perirhinal cortex; *P = 0.0349 for entorhinal cortex; *P = 0.0319 for amygdala, unpaired t test). Data are shown as mean + SEM