Fig. 8
From: A new AAV tool for highly preferentially targeting hippocampal CA2
M1-Cre induced DIO-hM4Di mediated chemogenetic inhibition of dCA2 impaired social memory. A Sociability test: inhibition mice (red, pink) (n = 11 mice) and control mice (blue, azure) (n = 17 mice) both preferred con-specifics mouse (S1) compared to sniffing time of empty container. B Sniffing time difference scores (S1 minus empty) were similar (p = 0.5060, two-tailed Student’s t-test). C Social novelty test: only control mice (blue, azure) preferred new unfamiliar mice (S2) over S1. D Sniffing time difference score (S2 minus S1) of CA2-inhibited group was significantly lower than that of control group (p < 0.0001). E Open-field behavioral test: duration in edge zone of inhibition mice (dark red) and control mice (dark blue) were similar (p = 0.3185). F Open-field behavioral test: duration in central zone of inhibition mice and control mice were similar (p = 0.7155). G Open-field behavioral test: total distances of inhibition mice (dark red) and control mice (dark blue) were similar (p = 0.0630). H Open-field behavioral test: mean velocities of inhibition mice and control mice were similar (p = 0.0531)