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Fig. 1 | Molecular Brain

Fig. 1

From: Activation of angiotensin-converting enzyme 2 produces an antidepressant-like effect via MAS receptors in mice

Fig. 1

Effects of DIZE on the tail suspension test in mice. A: The immobility time was measured 60 min after the administration of vehicle or DIZE (0.01, 0.1, 1 nmol). B: Time courses of the DIZE (1 nmol)-induced antidepressant-like effect in mice. C: Effects of A779 on the DIZE-induced reduction in immobility time in mice. Vehicle, DIZE (1 nmol) or DIZE (1 nmol) in combination with A779 (0.3 or 3 nmol) were administered 60 min prior to measurements. One-way ANOVA: F (3, 42) = 21.24, p < 0.0001, Fig. 1(A), F (4, 52) = 15.96, p < 0.0001, Fig. 1(C). Two-way ANOVA: [time: F (4, 95) = 4.671, p = 0.0017; treatment: F (1, 95) = 51.07, p < 0.0001; time × treatment: F (4, 95) = 6.079, p = 0.0002, Fig. 1(B)]. Values represent the means ± SEM. Numbers in parentheses indicate the number of animals in each group. **p < 0.01 compared with vehicle-treated mice. ##p < 0.01 compared with DIZE (1 nmol)-treated mice

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Molecular Brain

ISSN: 1756-6606