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Fig. 2 | Molecular Brain

Fig. 2

From: Activation of angiotensin-converting enzyme 2 produces an antidepressant-like effect via MAS receptors in mice

Fig. 2

Effects of Ang (1–7) on the tail suspension test in mice. A: The immobility time was measured 60 min after the administration of vehicle, Ang (1–7) (30 or 300 pmol) or Ang (1–7) (300 pmol) in combination with A779 (3 nmol). B: Time courses of the Ang (1–7) (300 pmol)-induced antidepressant-like effect in mice. One-way ANOVA: F (3, 37) = 5.265, p = 0.0040, Fig. 2(A). Two-way ANOVA: [time: F (2, 56) = 8.822, p = 0.0005; treatment: F (1, 56) = 26.82, p < 0.0001; time × treatment: F (2, 56) = 4.369, p = 0.0172, Fig. 2(B)]. Values represent the means ± SEM. Numbers in parentheses indicate the number of animals in each group. **p < 0.01 compared with vehicle-treated mice. #p < 0.05 compared with Ang (1–7) (300 pmol)-treated mice

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Molecular Brain

ISSN: 1756-6606