Fig. 1
Voxel-based analysis of TSPO overexpression in the rat striatum after LVn-CNTF injection. (a) Two-month-old rats were injected with LVn-CNTF (inflammation induction) and LVn-LacZ (control) in right and left striatum, respectively. (b) Hemisphere comparison at the voxel level using statistical parametric mapping (SPM) on [125I]CLINDE SPECT BPND images was performed using the small animal molecular imaging toolbox (SAMIT). Results are plotted in the Schwarz MRI from SAMIT and presented in each plan (coronal, horizontal and sagittal of the right hemisphere). A significant increase of TSPO binding was observed in the right (LVn-CNTF) compared to the left (LVn-LacZ, Control) striatum (n = 4 rats). Colored voxels indicated a difference with a p value < 0.01