Fig. 2
Volume-based analysis of TSPO overexpression in the rat striatum after LVn-CNTF injection. (a) Average images of [125I]CLINDE non-displaceable binding potential (BPND) acquired by single-photon emission computed tomography (SPECT) imaging in 4 rats and co-registered to the MRI atlas in the coronal (left), horizontal (center) and sagittal (right) planes. TSPO binding is increased in the right striatum compared to the left striatum. Scale bar = 0-0.77 BPND. (b) Quantification of [125I]CLINDE BPnd in the left (LVn-LacZ) and the right (LVn-CNTF) striatum demonstrating a clear overexpression of TSPO after LVn-CNTF injection (n = 4 rats). Paired t-test, * p < 0.05