Fig. 4
Cellular origin of TSPO overexpression after LVn-CNTF injection in the striatum of 2-month-old rats. Radioactivity measurement (% injected dose (% ID)/g of tissue) of [125I]CLINDE in astrocytes (a), endothelial cells (b), microglia (c) and neurons (d) of the left (LVn-LacZ, Control) and right (LVn-CNTF) striatum, showing an overexpression of TSPO in the right striatum compared to the left striatum in all cell types, except endothelial cells (n = 11 rats). Paired t-test, ** p < 0.01, *** p < 0.001. Radioactivity per cell (% ID/cell) in the different cell populations: astrocytes (e), endothelial cells (f), microglia (g) and neurons (h) of the left (LVn-LacZ, Control) and right (LVn-CNTF) striatum, showing an increase of TSPO binding sites in the LVn-CNTF compared to the LVn-LacZ-injected striatum in all cell populations, except endothelial cells (n = 11 rats). Paired t-test, * p < 0.05, *** p < 0.001