Fig. 1

LTD-IE includes firing frequency, rheobase current and AP onset time. A Firing frequency of wild-type through time. Firing frequency at the 1 h time point was significantly lower than all other time points (F _{3, 53} = 3.64, p = 0.018; sham vs. 1 h, p = 0.004; 1 h vs. 4 h, p = 0.045; 1 h vs. 24 h, p = 0.005). B Rheobase current of wild-type through time. Rheobase currents at 1- and 4 h time points were significantly higher than sham control (F _{3, 53} = 3.13, p = 0.033; sham vs. 1 h, p = 0.017; sham vs. 4 h, p = 0.018). C AP onset time of wild-type through time. AP onset time was significantly altered at the 1 h time point (F _{3, 53} = 3.12, p = 0.033; sham vs. 1 h, p = 0.020; 1 h vs. 4 h, p = 0.008). D Firing frequency of STIM1^PKO through time. There were no significant differences in firing frequency (F _{3, 53} = 1.31, p = 0.280). E Rheobase current of STIM^PKO through time. The rheobase current was not significantly altered in STIM1^PKO (F _{3, 53} = 0.737, p = 0.535) F AP onset time of STIM1^PKO through the time. There were no significant alterations (F _{3, 53} = 1.46, p = 0.237). Sample numbers of wild-type (sham n = 15, 1 h n = 10, 4 h n = 15, 24 h n = 17) and STIM1^PKO (sham n = 16, 1 h n = 15, 4 h n = 16, 24 h n = 10) are the same for all panels. One-way ANOVA with post hoc Fisher’s LSD test was used for all panels. The graphs are shown as mean ± SEM. *p < 0.05, **p < 0.01