Fig. 1From: Specific vulnerability of iPSC-derived motor neurons with TDP-43 gene mutation to oxidative stressGenome editing by CRISPR/Cas9. A The A382T mutation was in exon 6 of the TARDBP gene, the guide RNA targeted intron 5 upstream of the mutation, and the left arm and right arm were designed. B FRT sequences were inserted into the iPSC genome after gene editing. C WT KI and A382T KI strains were established, and mutations were introduced into the genome of iPSCsBack to article page