Fig. 4
Chronic pregabalin does not affect firing frequency of CA1 hippocampal neurons of S218L FHM-1 or wild-type mice. CA1 neurons were held at their intrinsic resting membrane potential and 10 pA steps were injected starting at – 100 pA. Frequency was calculated and plotted against current injected above threshold for a wild-type (WT) (Control n = 6, pregabalin n = 8 neurons) and d S218L mice (Control n = 7 neurons, pregabalin n = 5 neurons) treated with saline (grey dots) or chronic pregabalin (black dots). Error bars indicate ± SEM. Chronic pregabalin (black) does not affect resting membrane potential (RMP) or input resistance (Rin) of CA1 neurons from wild-type or S218L mice compared to controls (grey bars). Box plots showing b RMP from wild-type mice, c Input resistance from wild-type mice e RMP from S218L mice and f input resistance from S218L mice