Table 1 The effects of global alteration of the O-GlcNAcylation level on synaptic transmission
From: Modulation of synaptic transmission through O-GlcNAcylation
Animal | Brain region | Modulation method | O-GlcNAc level | Basal synaptic transmission | Synaptic plasticity | Note | Reference |
|---|---|---|---|---|---|---|---|
rat | CA1, DG (hippocampus) | GlcN&Thiamet-G | + | Â | Â | sIPSC -, mIPSC -, eIPSC - | [14] |
CA1 (hippocampus) | GlcN&Thiamet-G | + | Â | Â | neuronal excitability - | ||
rat | CA3-CA1 (hippocampus) | glucosamine (GlcN) | + | Â | LTP -, LTD + | Â | [8] |
OGA inhibitor (PUGNAc) | + | Â | LTD + | Â | |||
OGA inhibitor (Thiamet-G) | + | Â | LTP -, LTD + | Â | |||
mouse | CA1 (hippocampus) | OGA inhibitor (Thiamet-G) | + | n.e. | n.e. | neuronal excitability - | [13] |
mEPSC amplitude - | |||||||
GluA2 internalization + | |||||||
mouse | CA3-CA1 (hippocampus) | OGA inhibitor (9d) | + | not affected | LTP + | presynaptic release + | [9] |
mouse | CA3-CA1 (hippocampus) | conventional OGA +/- | + | not affected | LTP -, LTD - | mEPSC (not affected) | [10] |
AMPA/NMDA ratio (not affected) | |||||||
rat | CA3-CA1 (hippocampus) | OGT inhibitor (alloxan) | - | not affected | LTP - | GluA1 and GluA2 surface expression + | [12] |
mouse | CA3-CA1 (hippocampus) | OGT inhibitor (alloxan) | - | not affected | LTP - | Â | [9] |
mouse | CA3-CA1 (hippocampus) | forebrain specific OGT-cKO | - | not affected | LTP + | NR2A/NR2B + | [11] |
| Â | Â | LTD (not affected) | presynaptic release (not affected) |