Fig. 3
Effects of continuous administration of hNB001 on remote fear extinction in mice. a Schematic diagram showing fear extinction performed on mice. After auditory fear memory tests, the mice performed fear extinction (12 CS-ITI) once a day for three consecutive days. b hNB001 does not affect remote extinction 1/2/3 in adult mice (Saline, n = 9 mice, hNB001, n = 9 mice, Two-way ANOVA, Extinction 1, F (1,16) = 1.365, p = 0.2597; Extinction 2, F (1,16) = 1.792, p = 0.1993; Extinction 3, F (1,16) = 1.807, p = 0.1976). c hNB001 does not affect remote extinction 1/2/3 in aged mice (Saline, n = 8 mice, hNB001, n = 10 mice, Two-way ANOVA, Extinction 1, F (1,16) = 0.6108, p = 0.4459; Extinction 2, F (1,16) = 0.2314, p = 0.6370; Extinction 3, F (1,16) = 0.6563, p = 0.4298)