Selective enhancement of fear extinction by inhibiting neuronal adenylyl cyclase 1 (AC1) in aged mice

Table 1 Effects of AC1 deletion or pharmacological inhibition on behaviors in adult mice

Potential effects	AC1 KO	NB001	hNB001 (present study)	Gabapentin
Contextual/Auditory fear memory	No change [15]	No change [7, 27]	No change	N/A
Remote fear memory/extinction	No change (5 w/3 w) [32]	N/A	No change (30 d/30 d)	N/A
Other types of memory	Spatial memory: impaired [44]; Trace fear memory: no change [42]	N/A	Trace fear memory: no change; Trace fear extinction: improved	Spatial memory: improved [45]; Inhibitory avoidance: a single treatment: improved [46], repeated treatment: impaired [40]
LTP	ACC: blocked [5] Hippocampus: no change [15]	ACC: blocked [7, 27] Hippocampus: no change [7]	ACC: blocked [24]	ACC: no change [37] Hippocampus: no change [36]
Acute pain	No change [6]	No change [7, 27]	No change [24]	No change [38, 39]
Chronic neuropathic pain	Alleviated [6]	Alleviated [7, 27]	Alleviated [24]	Alleviated [47]
Motor function	No change [34]	No change [7, 27]	No change	No change [38]
Anxiety-like behavior	No change [35]	No change [7, 27]	No change	Improved [45]

ISSN: 1756-6606