Fig. 1

Comparison of the sleep architecture in nervous system-specific Tfap2b cKD and control mice. A Bi-hourly amount of wakefulness, NREM sleep, and REM sleep across 24 h in male mice. B Total amount of wakefulness, NREM sleep, and REM sleep during 24 h, light phase, and dark phase in male mice. N = 9 Tfap2b^flox/flox mice (grey), N = 9 Nes-Cre; Tfap2b^flox/+ mice (blue), N = 6 Nes-Cre; Tfap2b^flox/flox mice (pink). C, D Episode numbers (C) and durations (D) of wakefulness, NREM sleep, and REM sleep during 24 h, light phase, and dark phase. N = 8 Tfap2b^flox/flox mice (grey), N = 9 Nes-Cre; Tfap2b^flox/+ mice (blue), N = 6 Nes-Cre; Tfap2b^flox/flox mice (pink). ^# and ^‡ indicate a significant main effect of genotype and a significant interaction between genotype and time, respectively, in 2-way repeated-measures ANOVA (^#, ^‡p < 0.05, ^###, ^‡‡‡p < 0.001, ^####, ^‡‡‡‡p < 0.0001). ^† indicates significance in the 1-way ANOVA (^†p < 0.05, ^††p < 0.01, ^††††p < 0.0001). * indicates significance in the post-hoc Bonferroni multiple comparison test (*p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001). Data are presented as mean ± SEM