Fig. 5
From: Mutant α-synuclein causes death of human cortical neurons via ERK1/2 and JNK activation
A selective ERK1/2 inhibitor and a selective JNK inhibitor restore neuronal vulnerability of PD patient-derived cortical neurons. A Experimental timeline of treatment with PD98059 and SP600125 for PD patient-derived cortical neurons. B, C Quantification data of caspase-3/7 positive cells on day 15 in PD#1, PD#2-1, and PD#2-2, respectively. PD98059 and SP600125 were administered separately at concentrations of 0.03 μM, 0.125 μM, 0.5 μM, and 2 μM, and DMSO was used for comparison (n = 3; one-way ANOVA followed by Dunnet’s multiple comparison test; *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, N.S. not significant). Bar graphs represent mean ± SD. DMSO dimethyl sulfoxide