Fig. 3

Impaired remote spatial reference memory in Nlgn3^mf mutant mice. Spatial reference memory of the Nlgn3^hse mutant and littermate WT mice (a–d), and that of the Nlgn3^mf mutant and littermate WT mice (e–h) were examined using the Barnes maze test. a, e Number of errors before reaching the target hole across training. b, f Latency to reach the target hole across training. There was no significant difference between WT and Nlgn3^hse mutant mice, and between WT and Nlgn3^mf mutant mice during training session. Summary statistics are shown in each panel. c, d, g, h, Time spent around each hole in the probe trial conducted 24 h (c, g) and 1 month (d, h) after last training session. All values are presented as the mean ± SEM. *P < 0.05, Two-tailed t-test