Fig. 6

Reduced freezing levels of Nlgn3^hse mutant mice in the contextual fear conditioning with a 0.3 mA electric shock. Freezing responses during conditioning with footshocks of 0.3 mA (a, d), contextual test (b, e), and cued test (c, f) of the Nlgn3^hse mutant mice and their littermate WT mice (a–c) and of the Nlgn3^mf mutant mice and their littermate WT mice (d–f) are quantified. Bold lines and arrows represent tone and footshock, respectively. The Nlgn3^hse mutant mice showed significantly less freezing responses than their littermate WT mice during conditioning, while no significant difference was detected between the Nlgn3^mf mutant mice and their WT littermate. Summary statistics are shown in each panel. All values are presented as the mean ± SEM. *P < 0.05 and **P < 0.01, Two-tailed t-test in a