Fig. 1From: Synaptopodin is required for long-term depression at Schaffer collateral-CA1 synapsesSPKO mice show a deficit of LFS-LTD and HFS-LTP. (A) Diagram showing the positions of stimulating and recording electrodes at the Sc-CA1 synapses. (B) BCM curves in WT and SPKO for 2, 10 and 100Â Hz stimulation frequency. (C) (Left) Time course of normalized fEPSP in WT and SPKO following 2Â Hz (900 pulses) stimulation. (Right) Quantification of average synaptic modification in the last 10Â min of the recording. (D) (Left) Time course of normalized fEPSP in WT and SPKO following 10Â Hz (900 pulses) stimulation. (Right) Quantification of average synaptic modification in the last 10Â min of the recording. (E) (Left) Time course of normalized fEPSP in WT and SPKO following 100Â Hz (900 pulses) stimulation. (Right) Quantification of average synaptic modification in the last 10Â min of the recordingBack to article page