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  1. Research

    Disrupted-in-schizophrenia1 (DISC1) L100P mutation alters synaptic transmission and plasticity in the hippocampus and causes recognition memory deficits

    Disrupted-in-schizophrenia 1(DISC1) is a promising candidate susceptibility gene for a spectrum of psychiatric illnesses that share cognitive impairments in common, including schizophrenia, bipolar disorder and m...

    Lin Cui, Wei Sun, Ming Yu, Nan Li, Li Guo, Huating Gu and Yu Zhou

    Molecular Brain 2016 9:89

    Published on: 12 October 2016

  2. Research

    Modeling neurological diseases with induced pluripotent cells reprogrammed from immortalized lymphoblastoid cell lines

    Patient-specific induced pluripotent stem cells (iPSCs) facilitate understanding of the etiology of diseases, discovery of new drugs and development of novel therapeutic interventions. A frequently used starti...

    Koki Fujimori, Toshiki Tezuka, Hiroyuki Ishiura, Jun Mitsui, Koichiro Doi, Jun Yoshimura, Hirobumi Tada, Takuya Matsumoto, Miho Isoda, Ryota Hashimoto, Nubutaka Hattori, Takuya Takahashi, Shinichi Morishita, Shoji Tsuji, Wado Akamatsu and Hideyuki Okano

    Molecular Brain 2016 9:88

    Published on: 3 October 2016

  3. Research

    Pathological classification of human iPSC-derived neural stem/progenitor cells towards safety assessment of transplantation therapy for CNS diseases

    The risk of tumorigenicity is a hurdle for regenerative medicine using induced pluripotent stem cells (iPSCs). Although teratoma formation is readily distinguishable, the malignant transformation of iPSC deriv...

    Keiko Sugai, Ryuji Fukuzawa, Tomoko Shofuda, Hayato Fukusumi, Soya Kawabata, Yuichiro Nishiyama, Yuichiro Higuchi, Kenji Kawai, Miho Isoda, Daisuke Kanematsu, Tomoko Hashimoto-Tamaoki, Jun Kohyama, Akio Iwanami, Hiroshi Suemizu, Eiji Ikeda, Morio Matsumoto…

    Molecular Brain 2016 9:85

    Published on: 19 September 2016

  4. Research

    Increased phosphorylation of collapsin response mediator protein-2 at Thr514 correlates with β-amyloid burden and synaptic deficits in Lewy body dementias

    Collapsin response mediator protein-2 (CRMP2) regulates axonal growth cone extension, and increased CRMP2 phosphorylation may lead to axonal degeneration. Axonal and synaptic pathology is an important feature ...

    Huayang Xing, Yun-An Lim, Joyce R. Chong, Jasinda H. Lee, Dag Aarsland, Clive G. Ballard, Paul T. Francis, Christopher P. Chen and Mitchell K. P. Lai

    Molecular Brain 2016 9:84

    Published on: 8 September 2016

  5. Research

    Orchestrated activation of mGluR5 and CB1 promotes neuroprotection

    The metabotropic glutamate receptor 5 (mGluR5) and the cannabinoid receptor 1 (CB1) exhibit a functional interaction, as CB1 regulates pre-synaptic glutamate release and mGluR5 activation increases endocannabinoi...

    Edleusa M. L. Batista, Juliana G. Doria, Talita H. Ferreira-Vieira, Juliana Alves-Silva, Stephen S. G. Ferguson, Fabricio A. Moreira and Fabiola M. Ribeiro

    Molecular Brain 2016 9:80

    Published on: 20 August 2016

  6. Research

    Hypothermia inhibits the propagation of acute ischemic injury by inhibiting HMGB1

    Acute ischemic stroke causes significant chronic disability worldwide. We designed this study to clarify the mechanism by which hypothermia helps alleviate acute ischemic stroke. In a middle cerebral artery oc...

    Jung Ho Lee, Eun Jang Yoon, Jeho Seo, Adriana Kavoussi, Yong Eun Chung, Sung Phil Chung, Incheol Park, Chul Hoon Kim and Je Sung You

    Molecular Brain 2016 9:81

    Published on: 20 August 2016

  7. Research

    Differential arousal regulation by prokineticin 2 signaling in the nocturnal mouse and the diurnal monkey

    The temporal organization of activity/rest or sleep/wake rhythms for mammals is regulated by the interaction of light/dark cycle and circadian clocks. The neural and molecular mechanisms that confine the activ...

    Qun-Yong Zhou, Katherine J. Burton, Matthew L. Neal, Yu Qiao, Anumantha G. Kanthasamy, Yanjun Sun, Xiangmin Xu, Yuanye Ma and Xiaohan Li

    Molecular Brain 2016 9:78

    Published on: 18 August 2016

  8. Research

    Sex-dependent adaptive changes in serotonin-1A autoreceptor function and anxiety in Deaf1-deficient mice

    The C (-1019) G rs6295 promoter polymorphism of the serotonin-1A (5-HT1A) receptor gene is associated with major depression in several but not all studies, suggesting that compensatory mechanisms mediate resil...

    Christine Luckhart, Tristan J. Philippe, Brice Le François, Faranak Vahid-Ansari, Sean D. Geddes, Jean-Claude Béïque, Diane C. Lagace, Mireille Daigle and Paul R. Albert

    Molecular Brain 2016 9:77

    Published on: 3 August 2016

  9. Research

    Synaptic plasticity and spatial working memory are impaired in the CD mouse model of Williams-Beuren syndrome

    Mice heterozygous for a complete deletion (CD) equivalent to the most common deletion found in individuals with Williams-Beuren syndrome (WBS) recapitulate relevant features of the neurocognitive phenotype, su...

    Cristina Borralleras, Susana Mato, Thierry Amédée, Carlos Matute, Christophe Mulle, Luis A. Pérez-Jurado and Victoria Campuzano

    Molecular Brain 2016 9:76

    Published on: 2 August 2016

  10. Research

    Ca2+ in the dorsal raphe nucleus promotes wakefulness via endogenous sleep-wake regulating pathway in the rats

    Serotonergic neurons in the dorsal raphe nucleus (DRN) are involved in the control of sleep-wake states. Our previous studies have indicated that calcium (Ca2+) modulation in the DRN plays an important role in ra...

    Su-Ying Cui, Sheng-Jie Li, Xiang-Yu Cui, Xue-Qiong Zhang, Bin Yu, Yuan-Li Huang, Qing Cao, Ya-Ping Xu, Guang Yang, Hui Ding, Jin-Zhi Song, Hui Ye, Zhao-Fu Sheng, Zi-Jun Wang and Yong-He Zhang

    Molecular Brain 2016 9:71

    Published on: 26 July 2016

  11. Research

    In vitro characterization of neurite extension using induced pluripotent stem cells derived from lissencephaly patients with TUBA1A missense mutations

    Lissencephaly, or smooth brain, is a severe congenital brain malformation that is thought to be associated with impaired neuronal migration during corticogenesis. However, the exact etiology of lissencephaly i...

    Yohei Bamba, Tomoko Shofuda, Mitsuhiro Kato, Ritsuko K. Pooh, Yoko Tateishi, Jun-ichi Takanashi, Hidetsuna Utsunomiya, Miho Sumida, Daisuke Kanematsu, Hiroshi Suemizu, Yuichiro Higuchi, Wado Akamatsu, Denis Gallagher, Freda D. Miller, Mami Yamasaki, Yonehiro Kanemura…

    Molecular Brain 2016 9:70

    Published on: 19 July 2016

  12. Research

    Disrupted-in-schizophrenia 1 (DISC1) and Syntaphilin collaborate to modulate axonal mitochondrial anchoring

    In neuronal axons, the ratio of motile-to-stationary mitochondria is tightly regulated by neuronal activation, thereby meeting the need for local calcium buffering and maintaining the ATP supply. However, the ...

    Cana Park, Seol-Ae Lee, Ji-Ho Hong, Yeongjun Suh, Sung Jin Park, Bo Kyoung Suh, Youngsik Woo, Jinhyuk Choi, Ji-Won Huh, You-Me Kim and Sang Ki Park

    Molecular Brain 2016 9:69

    Published on: 2 July 2016

  13. Research

    Presynaptic muscarinic acetylcholine autoreceptors (M1, M2 and M4 subtypes), adenosine receptors (A1 and A2A) and tropomyosin-related kinase B receptor (TrkB) modulate the developmental synapse elimination process at the neuromuscular junction

    The development of the nervous system involves an initially exuberant production of neurons that make an excessive number of synaptic contacts. The initial overproduction of synapses promotes connectivity. Heb...

    Laura Nadal, Neus Garcia, Erica Hurtado, Anna Simó, Marta Tomàs, Maria A. Lanuza, Manel Santafé and Josep Tomàs

    Molecular Brain 2016 9:67

    Published on: 23 June 2016

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