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  1. Research

    The thalamic mGluR1-PLCβ4 pathway is critical in sleep architecture

    The transition from wakefulness to a nonrapid eye movement (NREM) sleep state at the onset of sleep involves a transition from low-voltage, high-frequency irregular electroencephalography (EEG) waveforms to la...

    Joohyeon Hong, Jungryun Lee, Kiyeong Song, Go Eun Ha, Yong Ryoul Yang, Ji Su Ma, Masahiro Yamamoto, Hee-Sup Shin, Pann-Ghill Suh and Eunji Cheong

    Molecular Brain 2016 9:100

    Published on: 21 December 2016

  2. Research

    The anti-inflammatory role of extranuclear apurinic/apyrimidinic endonuclease 1/redox effector factor-1 in reactive astrocytes

    Apurinic/apyrimidinic endonuclease 1 (APE1), a ubiquitous multipurpose protein, is also known as redox effector factor-1 (Ref-1). It is involved in DNA repair and redox signaling and, in turn, oxidative stress...

    Hyunjung Baek, Chae Seong Lim, Hee Sun Byun, Hyun Sil Cho, Yu Ran Lee, Yong Sup Shin, Hyun-Woo Kim, Byeong Hwa Jeon, Dong Woon Kim, Jinpyo Hong, Gang Min Hur and Jin Bong Park

    Molecular Brain 2016 9:99

    Published on: 16 December 2016

  3. Research

    CHD7 promotes proliferation of neural stem cells mediated by MIF

    Macrophage migration inhibitory factor (MIF) plays an important role in supporting the proliferation and/or survival of murine neural stem/progenitor cells (NSPCs); however, the downstream effectors of this fa...

    Shigeki Ohta, Tomonori Yaguchi, Hironobu Okuno, Hervé Chneiweiss, Yutaka Kawakami and Hideyuki Okano

    Molecular Brain 2016 9:96

    Published on: 13 December 2016

  4. Research

    Oxytocin is implicated in social memory deficits induced by early sensory deprivation in mice

    Early-life sensory input plays a crucial role in brain development. Although deprivation of orofacial sensory input at perinatal stages disrupts the establishment of the barrel cortex and relevant callosal con...

    Jin-Bao Zhang, Ling Chen, Zhu-Man Lv, Xue-Yuan Niu, Can-Can Shao, Chan Zhang, Michal Pruski, Ying Huang, Cong-Cong Qi, Ning-Ning Song, Bing Lang and Yu-Qiang Ding

    Molecular Brain 2016 9:98

    Published on: 13 December 2016

  5. Research

    Increased alternate splicing of Htr2c in a mouse model for Prader-Willi syndrome leads disruption of 5HT2C receptor mediated appetite

    Alternate splicing of serotonin (5-hydroxytryptamine; 5-HT) 2C receptor (5-HT2CR) pre-RNA is negatively regulated by the small nucleolar RNA, Snord115, loss of which is observed in nearly all individuals with Pra...

    Alastair S. Garfield, Jennifer R. Davies, Luke K. Burke, Hannah V. Furby, Lawrence S. Wilkinson, Lora K. Heisler and Anthony R. Isles

    Molecular Brain 2016 9:95

    Published on: 8 December 2016

  6. Research

    Heantos-4, a natural plant extract used in the treatment of drug addiction, modulates T-type calcium channels and thalamocortical burst-firing

    Heantos-4 is a refined combination of plant extracts currently approved to treat opiate addiction in Vietnam. In addition to its beneficial effects on withdrawal and prevention of relapse, reports of sedation ...

    Stuart M. Cain, Soyon Ahn, Esperanza Garcia, Yiming Zhang, Zeina Waheed, John R. Tyson, Yi Yang, Tran Van Sung, Anthony G. Phillips and Terrance P. Snutch

    Molecular Brain 2016 9:94

    Published on: 5 December 2016

  7. Research

    Personalized medicine approach confirms a milder case of ABAT deficiency

    ABAT deficiency (OMIM 613163) is a rare inborn error of metabolism caused by recessive variants in the gene 4-aminobutyric acid transaminase (ABAT), which is responsible for both the catalysis of GABA and main...

    A. Besse, A. K. Petersen, J. V. Hunter, V. Appadurai, S. R. Lalani and P. E. Bonnen

    Molecular Brain 2016 9:93

    Published on: 1 December 2016

  8. Research

    ApCPEB4, a non-prion domain containing homolog of ApCPEB, is involved in the initiation of long-term facilitation

    Two pharmacologically distinct types of local protein synthesis are required for synapse- specific long-term synaptic facilitation (LTF) in Aplysia: one for initiation and the other for maintenance. ApCPEB, a rap...

    Seung-Hee Lee, Jaehoon Shim, Ye-Hwang Cheong, Sun-Lim Choi, Yong-Woo Jun, Sue-Hyun Lee, Yeon-Su Chae, Jin-Hee Han, Yong-Seok Lee, Jin-A Lee, Chae-Seok Lim, Kausik Si, Stefan Kassabov, Igor Antonov, Eric R. Kandel, Bong-Kiun Kaang…

    Molecular Brain 2016 9:91

    Published on: 22 October 2016

  9. Research

    Disrupted-in-schizophrenia1 (DISC1) L100P mutation alters synaptic transmission and plasticity in the hippocampus and causes recognition memory deficits

    Disrupted-in-schizophrenia 1(DISC1) is a promising candidate susceptibility gene for a spectrum of psychiatric illnesses that share cognitive impairments in common, including schizophrenia, bipolar disorder and m...

    Lin Cui, Wei Sun, Ming Yu, Nan Li, Li Guo, Huating Gu and Yu Zhou

    Molecular Brain 2016 9:89

    Published on: 12 October 2016

  10. Research

    Modeling neurological diseases with induced pluripotent cells reprogrammed from immortalized lymphoblastoid cell lines

    Patient-specific induced pluripotent stem cells (iPSCs) facilitate understanding of the etiology of diseases, discovery of new drugs and development of novel therapeutic interventions. A frequently used starti...

    Koki Fujimori, Toshiki Tezuka, Hiroyuki Ishiura, Jun Mitsui, Koichiro Doi, Jun Yoshimura, Hirobumi Tada, Takuya Matsumoto, Miho Isoda, Ryota Hashimoto, Nubutaka Hattori, Takuya Takahashi, Shinichi Morishita, Shoji Tsuji, Wado Akamatsu and Hideyuki Okano

    Molecular Brain 2016 9:88

    Published on: 3 October 2016

  11. Research

    Pathological classification of human iPSC-derived neural stem/progenitor cells towards safety assessment of transplantation therapy for CNS diseases

    The risk of tumorigenicity is a hurdle for regenerative medicine using induced pluripotent stem cells (iPSCs). Although teratoma formation is readily distinguishable, the malignant transformation of iPSC deriv...

    Keiko Sugai, Ryuji Fukuzawa, Tomoko Shofuda, Hayato Fukusumi, Soya Kawabata, Yuichiro Nishiyama, Yuichiro Higuchi, Kenji Kawai, Miho Isoda, Daisuke Kanematsu, Tomoko Hashimoto-Tamaoki, Jun Kohyama, Akio Iwanami, Hiroshi Suemizu, Eiji Ikeda, Morio Matsumoto…

    Molecular Brain 2016 9:85

    Published on: 19 September 2016

  12. Research

    Increased phosphorylation of collapsin response mediator protein-2 at Thr514 correlates with β-amyloid burden and synaptic deficits in Lewy body dementias

    Collapsin response mediator protein-2 (CRMP2) regulates axonal growth cone extension, and increased CRMP2 phosphorylation may lead to axonal degeneration. Axonal and synaptic pathology is an important feature ...

    Huayang Xing, Yun-An Lim, Joyce R. Chong, Jasinda H. Lee, Dag Aarsland, Clive G. Ballard, Paul T. Francis, Christopher P. Chen and Mitchell K. P. Lai

    Molecular Brain 2016 9:84

    Published on: 8 September 2016

  13. Research

    Orchestrated activation of mGluR5 and CB1 promotes neuroprotection

    The metabotropic glutamate receptor 5 (mGluR5) and the cannabinoid receptor 1 (CB1) exhibit a functional interaction, as CB1 regulates pre-synaptic glutamate release and mGluR5 activation increases endocannabinoi...

    Edleusa M. L. Batista, Juliana G. Doria, Talita H. Ferreira-Vieira, Juliana Alves-Silva, Stephen S. G. Ferguson, Fabricio A. Moreira and Fabiola M. Ribeiro

    Molecular Brain 2016 9:80

    Published on: 20 August 2016

  14. Research

    Hypothermia inhibits the propagation of acute ischemic injury by inhibiting HMGB1

    Acute ischemic stroke causes significant chronic disability worldwide. We designed this study to clarify the mechanism by which hypothermia helps alleviate acute ischemic stroke. In a middle cerebral artery oc...

    Jung Ho Lee, Eun Jang Yoon, Jeho Seo, Adriana Kavoussi, Yong Eun Chung, Sung Phil Chung, Incheol Park, Chul Hoon Kim and Je Sung You

    Molecular Brain 2016 9:81

    Published on: 20 August 2016

  15. Research

    Differential arousal regulation by prokineticin 2 signaling in the nocturnal mouse and the diurnal monkey

    The temporal organization of activity/rest or sleep/wake rhythms for mammals is regulated by the interaction of light/dark cycle and circadian clocks. The neural and molecular mechanisms that confine the activ...

    Qun-Yong Zhou, Katherine J. Burton, Matthew L. Neal, Yu Qiao, Anumantha G. Kanthasamy, Yanjun Sun, Xiangmin Xu, Yuanye Ma and Xiaohan Li

    Molecular Brain 2016 9:78

    Published on: 18 August 2016

  16. Research

    Sex-dependent adaptive changes in serotonin-1A autoreceptor function and anxiety in Deaf1-deficient mice

    The C (-1019) G rs6295 promoter polymorphism of the serotonin-1A (5-HT1A) receptor gene is associated with major depression in several but not all studies, suggesting that compensatory mechanisms mediate resil...

    Christine Luckhart, Tristan J. Philippe, Brice Le François, Faranak Vahid-Ansari, Sean D. Geddes, Jean-Claude Béïque, Diane C. Lagace, Mireille Daigle and Paul R. Albert

    Molecular Brain 2016 9:77

    Published on: 3 August 2016

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