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  1. Short report

    Absence of neurological abnormalities in mice homozygous for the Polr3a G672E hypomyelinating leukodystrophy mutation

    Recessive mutations in the ubiquitously expressed POLR3A gene cause one of the most frequent forms of childhood-onset hypomyelinating leukodystrophy (HLD): POLR3-HLD. POLR3A encodes the largest subunit of RNA Pol...

    Karine Choquet, Sharon Yang, Robyn D. Moir, Diane Forget, Roxanne Larivière, Annie Bouchard, Christian Poitras, Nicolas Sgarioto, Marie-Josée Dicaire, Forough Noohi, Timothy E. Kennedy, Joseph Rochford, Geneviève Bernard, Martin Teichmann, Benoit Coulombe, Ian M. Willis…

    Molecular Brain 2017 10:13

    Published on: 13 April 2017

  2. Research

    Neuroligin 3 R451C mutation alters electroencephalography spectral activity in an animal model of autism spectrum disorders

    Human studies demonstrate that sleep impairment is a concurrent comorbidity of autism spectrum disorders (ASD), but its etiology remains largely uncertain. One of the prominent theories of ASD suggests that an...

    Jackie J. Liu, Kevin P. Grace, Richard L. Horner, Miguel A. Cortez, Yiwen Shao and Zhengping Jia

    Molecular Brain 2017 10:10

    Published on: 7 April 2017

  3. Research

    Comparative analysis of A-to-I editing in human and non-human primate brains reveals conserved patterns and context-dependent regulation of RNA editing

    A-to-I RNA editing is an important process for generating molecular diversity in the brain through modification of transcripts encoding several proteins important for neuronal signaling. We investigated the re...

    Richard T. O’Neil, Xiaojing Wang, Michael V. Morabito and Ronald B. Emeson

    Molecular Brain 2017 10:11

    Published on: 6 April 2017

  4. Review

    Molecules in pain and sex: a developing story

    Microglia are dynamic immune cells with diverse roles in maintaining homeostasis of the central nervous system. Dysregulation of microglia has been critically implicated in the genesis of neuropathic pain. Per...

    Josiane C. S. Mapplebeck, Simon Beggs and Michael W. Salter

    Molecular Brain 2017 10:9

    Published on: 7 March 2017

  5. Research

    Proteasome impairment in neural cells derived from HMSN-P patient iPSCs

    Hereditary motor and sensory neuropathy with proximal dominant involvement (HMSN-P) is caused by a heterozygous mutation (P285L) in Tropomyosin-receptor kinase Fused Gene (TFG), histopathologically characterized ...

    Nagahisa Murakami, Keiko Imamura, Yuishin Izumi, Naohiro Egawa, Kayoko Tsukita, Takako Enami, Takuya Yamamoto, Toshitaka Kawarai, Ryuji Kaji and Haruhisa Inoue

    Molecular Brain 2017 10:7

    Published on: 15 February 2017

  6. Review

    TBK1: a new player in ALS linking autophagy and neuroinflammation

    Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disorder affecting motor neurons, resulting in progressive muscle weakness and death by respiratory failure. Protein and RNA aggregates a...

    James A. Oakes, Maria C. Davies and Mark O. Collins

    Molecular Brain 2017 10:5

    Published on: 2 February 2017

  7. Research

    The neurotoxicity of amyloid β-protein oligomers is reversible in a primary neuron model

    Alzheimer’s disease (AD) is characterized by the accumulation of extracellular amyloid β-protein (Aβ) and intracellular hyperphosphorylated tau proteins. Recent evidence suggests that soluble Aβ oligomers elic...

    Daisuke Tanokashira, Naomi Mamada, Fumiko Yamamoto, Kaori Taniguchi, Akira Tamaoka, Madepalli K. Lakshmana and Wataru Araki

    Molecular Brain 2017 10:4

    Published on: 31 January 2017

  8. Research

    Acute stress enhances the glutamatergic transmission onto basoamygdala neurons embedded in distinct microcircuits

    Amygdala activation is known to be critical for the processing of stressful events in brain. Recent studies have shown that the projection neurons (PNs) in amygdala, although architecturally intermingled, are ...

    Chen Song, Wen-Hua Zhang, Xue-Hui Wang, Jun-Yu Zhang, Xiao-Li Tian, Xiao-Ping Yin and Bing-Xing Pan

    Molecular Brain 2017 10:3

    Published on: 9 January 2017

  9. Research

    Treatment of intermittent hypoxia increases phosphorylated tau in the hippocampus via biological processes common to aging

    Sleep-disordered breathing produces cognitive impairments, and is possibly associated with Alzheimer disease (AD). Intermittent hypoxia treatment (IHT), an experimental model for sleep-disordered breathing, re...

    Sosuke Yagishita, Seiya Suzuki, Keisuke Yoshikawa, Keiko Iida, Ayako Hirata, Masahiko Suzuki, Akihiko Takashima, Kei Maruyama, Akira Hirasawa and Takeo Awaji

    Molecular Brain 2017 10:2

    Published on: 5 January 2017

  10. Research

    Tat-HSP22 inhibits oxidative stress-induced hippocampal neuronal cell death by regulation of the mitochondrial pathway

    Oxidative stress plays an important role in the progression of various neuronal diseases including ischemia. Heat shock protein 22 (HSP22) is known to protect cells against oxidative stress. However, the prote...

    Hyo Sang Jo, Dae Won Kim, Min Jea Shin, Su Bin Cho, Jung Hwan Park, Chi Hern Lee, Eun Ji Yeo, Yeon Joo Choi, Hyeon Ji Yeo, Eun Jeong Sohn, Ora Son, Sung-Woo Cho, Duk-Soo Kim, Yeon Hee Yu, Keun Wook Lee, Jinseu Park…

    Molecular Brain 2017 10:1

    Published on: 4 January 2017

  11. Research

    The thalamic mGluR1-PLCβ4 pathway is critical in sleep architecture

    The transition from wakefulness to a nonrapid eye movement (NREM) sleep state at the onset of sleep involves a transition from low-voltage, high-frequency irregular electroencephalography (EEG) waveforms to la...

    Joohyeon Hong, Jungryun Lee, Kiyeong Song, Go Eun Ha, Yong Ryoul Yang, Ji Su Ma, Masahiro Yamamoto, Hee-Sup Shin, Pann-Ghill Suh and Eunji Cheong

    Molecular Brain 2016 9:100

    Published on: 21 December 2016

  12. Research

    The anti-inflammatory role of extranuclear apurinic/apyrimidinic endonuclease 1/redox effector factor-1 in reactive astrocytes

    Apurinic/apyrimidinic endonuclease 1 (APE1), a ubiquitous multipurpose protein, is also known as redox effector factor-1 (Ref-1). It is involved in DNA repair and redox signaling and, in turn, oxidative stress...

    Hyunjung Baek, Chae Seong Lim, Hee Sun Byun, Hyun Sil Cho, Yu Ran Lee, Yong Sup Shin, Hyun-Woo Kim, Byeong Hwa Jeon, Dong Woon Kim, Jinpyo Hong, Gang Min Hur and Jin Bong Park

    Molecular Brain 2016 9:99

    Published on: 16 December 2016

  13. Research

    CHD7 promotes proliferation of neural stem cells mediated by MIF

    Macrophage migration inhibitory factor (MIF) plays an important role in supporting the proliferation and/or survival of murine neural stem/progenitor cells (NSPCs); however, the downstream effectors of this fa...

    Shigeki Ohta, Tomonori Yaguchi, Hironobu Okuno, Hervé Chneiweiss, Yutaka Kawakami and Hideyuki Okano

    Molecular Brain 2016 9:96

    Published on: 13 December 2016

  14. Research

    Oxytocin is implicated in social memory deficits induced by early sensory deprivation in mice

    Early-life sensory input plays a crucial role in brain development. Although deprivation of orofacial sensory input at perinatal stages disrupts the establishment of the barrel cortex and relevant callosal con...

    Jin-Bao Zhang, Ling Chen, Zhu-Man Lv, Xue-Yuan Niu, Can-Can Shao, Chan Zhang, Michal Pruski, Ying Huang, Cong-Cong Qi, Ning-Ning Song, Bing Lang and Yu-Qiang Ding

    Molecular Brain 2016 9:98

    Published on: 13 December 2016

  15. Research

    Increased alternate splicing of Htr2c in a mouse model for Prader-Willi syndrome leads disruption of 5HT2C receptor mediated appetite

    Alternate splicing of serotonin (5-hydroxytryptamine; 5-HT) 2C receptor (5-HT2CR) pre-RNA is negatively regulated by the small nucleolar RNA, Snord115, loss of which is observed in nearly all individuals with Pra...

    Alastair S. Garfield, Jennifer R. Davies, Luke K. Burke, Hannah V. Furby, Lawrence S. Wilkinson, Lora K. Heisler and Anthony R. Isles

    Molecular Brain 2016 9:95

    Published on: 8 December 2016

  16. Research

    Heantos-4, a natural plant extract used in the treatment of drug addiction, modulates T-type calcium channels and thalamocortical burst-firing

    Heantos-4 is a refined combination of plant extracts currently approved to treat opiate addiction in Vietnam. In addition to its beneficial effects on withdrawal and prevention of relapse, reports of sedation ...

    Stuart M. Cain, Soyon Ahn, Esperanza Garcia, Yiming Zhang, Zeina Waheed, John R. Tyson, Yi Yang, Tran Van Sung, Anthony G. Phillips and Terrance P. Snutch

    Molecular Brain 2016 9:94

    Published on: 5 December 2016

  17. Research

    Personalized medicine approach confirms a milder case of ABAT deficiency

    ABAT deficiency (OMIM 613163) is a rare inborn error of metabolism caused by recessive variants in the gene 4-aminobutyric acid transaminase (ABAT), which is responsible for both the catalysis of GABA and main...

    A. Besse, A. K. Petersen, J. V. Hunter, V. Appadurai, S. R. Lalani and P. E. Bonnen

    Molecular Brain 2016 9:93

    Published on: 1 December 2016

  18. Research

    ApCPEB4, a non-prion domain containing homolog of ApCPEB, is involved in the initiation of long-term facilitation

    Two pharmacologically distinct types of local protein synthesis are required for synapse- specific long-term synaptic facilitation (LTF) in Aplysia: one for initiation and the other for maintenance. ApCPEB, a rap...

    Seung-Hee Lee, Jaehoon Shim, Ye-Hwang Cheong, Sun-Lim Choi, Yong-Woo Jun, Sue-Hyun Lee, Yeon-Su Chae, Jin-Hee Han, Yong-Seok Lee, Jin-A Lee, Chae-Seok Lim, Kausik Si, Stefan Kassabov, Igor Antonov, Eric R. Kandel, Bong-Kiun Kaang…

    Molecular Brain 2016 9:91

    Published on: 22 October 2016

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