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Table 1 IC50s of known blockers and anthranilic acid derivatives.

From: Development of selective blockers for Ca2+-activated Cl- channel using Xenopus laevis oocytes with an improved drug screening strategy

Compound number

Chemical compound

IC50 *

IC50

n

a-1

DIDS

48

10.7

6

a-2

NPPB (5-nitro-2-(3-phenylpropylamino)benzoic acid)

22–68

32.3

6

a-3

9-AC (9-anthracene carboxylic acid)

10.3

94.3

5

a-4

Niflumic acid

17

37.3

7

a-5

Flufenamic acid (N-(3-Trifluoromethylphenyl)anthranilic acid)

28

35.4

6

a-6

Mefenamic acid

 

44.5

6

a-7

N-Phenylanthranilic acid

 

88.1

6

a-8

5-Nitro-N-phenylanthranilic acid

 

42.5

8

b-1

N-(2-Nitrophenyl)anthranilic acid

 

LP

7

b-2

N-(3-Nitrophenyl)anthranilic acid

 

32.1

7

b-3

N-(4-Nitrophenyl)anthranilic acid

 

17.8

6

b-4

5-Nitro-N-(4-nitrophenyl)anthranilic acid

 

15.4

5

b-5

N-(2-Trifluoromethylphenyl)anthranilic acid

 

29.5

6

b-6

N-(4-Trifluoromethylphenyl)anthranilic acid

 

6.0

6

b-7

N-(4-Fluoro-3-trifluoromethylphenyl)anthranilic acid

 

14.7

6

c-1

N-(4-Fluorophenyl)anthranilic acid

 

63.1

6

c-2

N-(4-Chlorophenyl)anthranilic acid

 

11.3

6

c-3

N-(4-Methylphenyl)anthranilic acid

 

55.3

7

c-4

N-(4-Isopropylphenyl)anthranilic acid

 

17.0

6

c-5

N-(4-tert-Butylphenyl)anthranilic acid

 

22.9

7

c-6

N-(4-Decylphenyl)anthranilic acid

 

LP

6

c-7

N-(4-Methoxyphenyl)anthranilic acid

 

102.3

5

  1. IC50 * means IC50 previously studied. LP: Low Potency. IC50 > 200 μM n indicates number of oocytes.
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Molecular Brain

ISSN: 1756-6606