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Figure 5 | Molecular Brain

Figure 5

From: Abelson tyrosine kinase links PDGFbeta receptor activation to cytoskeletal regulation of NMDA receptors in CA1 hippocampal neurons

Figure 5

Abelson kinase associates with PDGFβ receptors and inhibits NMDA receptor currents in a ROCK-dependent manner. Abelson kinase (Abl) physically associates with PDGFβ receptors, PLCγ, and Src in hippocampal neurons. Upon activation of PDGFβ receptors, Abelson kinase is tyrosine-phosphorylated and dissociates from the receptor. Introduction of Abelson kinase into isolated hippocampal neurons robustly inhibits NMDA receptor currents in a ROCK-dependent manner, possibly through changes in the actin cytoskeleton.

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