Figure 1

Dysregulated Behaviors of Alpha-CaMKII+/- Mice. (A, B) In the spatial working memory version of the eight-arm radial maze, the alpha-CaMKII+/- mice performed significantly worse than control mice with respect to the number of different arm choices in the first eight entries (P = 0.0022) and made significantly more revisiting errors than controls (P = 0.0026). (C) Mutant mice had normal performance in reference memory tasks in the eight-arm radial maze (P = 0.6394). Activity level of control mice (D-F) and alpha-CaMKII+/- mice (G-I) in their home cage. Mutant mice were hyperactive and showed a periodic mood-change-like activity pattern. (J) The variability in the activity in the home cage during the dark period was greater in mutant mice (coefficient of variation, P = 0.0088, Mann-Whitney U test). (K) The activity of mutant mice increased throughout the dark period (genotype effect, P < 0.0001, interaction between genotype and time, P < 0.0001, repeated measures ANOVA). Error bars indicate s.e.m.