Comprehensive behavioral phenotyping of calpastatin-knockout mice

Table 1 General characteristics of CS-KO mice.

	WT	CS-KO
*Number of animals*	20	18
*Physical characteristics*
- Weight (g)	26.2 (± 0.33)	27.1 (± 0.40)
- Body temperature (°C)	36.9 (± 0.20)	37.1 (± 0.18)
- Whiskers (% with)	100	89
- Fur (% with normal fur)	100	100
*Sensory and motor reflexes*
- Ear twitch (% with normal response)	100	83
- Key jangling (% with normal response)	95	89
- Whisker twitch	100	94
- Righting reflex	100	100
*Pain test*
- Hot plate (latency; seconds)	6.75 (± 0.349)	6.05 (± 0.364)
*Motor tests*
- Wire hang (% stayed up to 60 s)	95	94
- Grip strength (N)	0.893 (± 0.03)	0.825 (± 0.03)

No significant differences between genotypes were detected in physical characteristics (weight, body temperature, whiskers and fur), sensory and motor reflex (ear twitch response, key-jangling response and righting reflex), hot plate test (latency to the first paw response), and muscular abilities (number of animals that stayed up to 60 sec in wire hang test and grip strength).

ISSN: 1756-6606