Skip to main content
Figure 1 | Molecular Brain

Figure 1

From: Induction- and conditioning-protocol dependent involvement of NR2B-containing NMDA receptors in synaptic potentiation and contextual fear memory in the hippocampal CA1 region of rats

Figure 1

NR2B-NMDARs are required for LTP induced by spike-timing protocol in area CA1. A. Schematic diagram of the spike-timing protocol. B. Spike-timing protocol, as indicated by the arrow, induced a significant LTP in CA1 pyramidal neurons (n = 8). Sample traces of EPSC are the averages of 7 consecutive responses recorded during 5–10 min and 25–30 min, respectively. C. Bath application of ifenprodil partially blocked the LTP. n = 8 neurons D. Bath application of Ro25-6981 partially blocked the LTP. n = 7 neurons for 0.3 μM Ro25-6981; n = 8 neurons for 3 μM Ro25-6981. E. Histograms showing the effects of ifenprodil and Ro25-6981 on the LTP. *p < 0.05 vs. control. F. NR2A-NMDARs are required for LTP induced by spike-timing protocol in area CA1. Bath application of NVP-AAM077 blocked the LTP. n = 7 neurons. inset: Histogram showing the effect of NVP-AAM077 on the LTP. *p < 0.05 vs. control.

Back to article page

Molecular Brain

ISSN: 1756-6606