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Figure 6 | Molecular Brain

Figure 6

From: Induction- and conditioning-protocol dependent involvement of NR2B-containing NMDA receptors in synaptic potentiation and contextual fear memory in the hippocampal CA1 region of rats

Figure 6

NR2B-NMDARs are required for the acquisition of contextual fear memory induced by the five but not one CS-US pairing conditioning. A. Pre-training intra-CA1 inhibition of NR2B-NMDARs had no impact on, while inhibition of NR2A-NMDARs impaired 48-h contextual fear memory induced by the single CS-US pairing protocol (A1). The acquisition of auditory fear memory was intact (A2). The result with Ro25-6981 was reported in the previous study (Zhao et al., 2005). *p < 0.05 vs. vehicle B. Pre-training intra-CA1 inhibition of NR2B- or NR2A-NMDARs impaired 48-h contextual fear memory induced by the five CS-US pairing protocol (B1). The acquisition of auditory fear memory was intact (B2). **p < 0.01 vs. vehicle. C. Reconstruction of the infusion sites in the CA1 region. Filled squares: vehicle; Open circles: 0.012 μg NVP-AAM077; Filled circles: 0.12 μg NVP-AAM077; Open triangles: ifenprodil; Grey squares: Ro25-6981. D. A representative coronal section showing an infusion site of ifenprodil in the CA1 region.

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