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Figure 1 | Molecular Brain

Figure 1

From: Dynamic regulation of RNA editing of ion channels and receptors in the mammalian nervous system

Figure 1

Model of the conformational changes during ADAR2-mediated RNA editing. The deaminase domain is represented by the blue box; double-strand RNA binding motif (dsRBM), by the yellow boxes. In the absence of RNA, ADAR2 protein is inactive because the N-terminal domain prevents the association of dsRBMII and catalytic domain with substrate. In the presence of RNA substrate with specific secondary elements and sufficient length, conformational change frees up the catalytic domain, and allows both dsRBM and catalytic domain to bind to RNA substrate, as well as activation of enzyme. After the edited site is converted from A (in red) to a G (in red) by ADAR2, the RNA substrate is released for translation. (Figure adapted from Macbeth et al [26].)

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